2011年8月2日星期二

Protecting Mice and Men

Mice share 95% of the same genes as humans and have become an effective and efficient model for genetic research pertaining to human diseases.It's hard to beat the versatility of third party merchant account on a production line. The Jackson Laboratory, an independent and nonprofit biomedical research institution with locations in Bar Harbor, Maine, and Sacramento, Calif., is a distributor of human disease mouse models.

Jackson's mission is to discover the genetic basis for preventing, treating and curing human diseases. The lab also provides educational and research resources to the worldwide biomedical research community by serving as a global collection and distribution point for mouse models of human diseases through its JAX Mice & Services division. Currently, Jackson provides more than 5,000 varieties of mice, with approximately 135 strains in active production colonies,Graphene is not a semiconductor, not an oil paintings for sale , and not a metal, an additional 1,000 strains in small live colonies and the remainder available as cryopreserved germplasm (sperm or embryos),the Air purifier are swollen blood vessels of the rectum. which can be readily recovered upon request. Its repository has more than 2,100 targeted and 1,000 transgenic mutant mouse lines with 500 new lines imported each year. Many are models for cancer, heart disease, Alzheimer's, ALS, diabetes and various other autoimmune diseases. In 2010, 2.9 million JAX mice were distributed to approximately 19,000 investigators in more than 800 institutions worldwide.

To better serve the biomedical research community and increase its capability to manage the health of a growing number of mouse lines, Jackson opened a new 22,500 ft2 Importation and Isolation Facility with a 5,000-cage capacity quarantine room for receiving, housing and processing all imported mice of unknown health status delivered from institutions.

In the quarantine room, Innovive disposable caging is used, and each week technicians perform complete cage changes on every mouse¡ªchecking the animal, removing old bedding, feeding and watering and taking blood samples. Because each cage is considered a contaminant because of the unknown health of the mice, it can only be opened and changed within a biological safety cabinet. To protect the safety of the technicians and the mice, it is critical to keep the work environment absolutely free from contamination.

Changing the cages in the old mouse importation building was inefficient. It required moving the cages to stationary biological safety cabinets situated on the room's perimeter¡ªa difficult task given the heavy cage racks had to be moved 20 to 30 ft, locking and unlocking them along the way. As such, the new Importation and Isolation Facility presented an opportunity for Jackson to improve workflow efficiencies in the quarantine room and assess the equipment used in order to make the cage changing process faster and more ergonomic to help reduce repetitive motion injuries and fatigue.

During the design phase, engineers and facility managers from Jackson worked together to develop a new workflow process. They concluded that a biological safety cabinet that could be accessed from both sides and placed in line with a row of cage racks (instead of at the end of an aisle) would create a more ergonomic and efficient process.

At the time, a biological safety cabinet with a double-sided capability was not available in the marketplace.These girls have never had a cube puzzle in their lives! In the summer of 2009, Jackson approached several biological safety cabinet (BSC) manufacturers, and found The Baker Co., located in Sanford, Maine,If so, you may have a zentai . to be the most qualified manufacturer to collaborate on the development of a new cabinet with such unique design and functionality. The Baker Co. was selected for several reasons, including 60 years of expertise in designing personnel protection and containment equipment, willingness to offer creative solutions and work collaboratively with the Jackson team and the ability to meet an aggressive timeline to have the new biological safety cabinet tested and ready for operation by July 2010.

没有评论:

发表评论